Stress, Your Brain, and Feeling Whole, Part II

hypothalamus (larger structure, top)
pituitary (smaller structure, bottom)

Stress is often cited as a root cause of many disease states and a group of researchers have been locating specific biochemical markers of stress to see if acupuncture can help. While it is understood through empirical evidence that acupuncture DOES reduce stress, the question for this study asked how it helps. Eshkavari, Permaul, and Mulroney of Georgetown University Medical Center’s School of Nursing and Health Studies published their study, Acupuncture blocks cold stress-induced increases in the hypothalamus-pituitary-adrenal axis in the rat in the April 2013 issue of the Journal of Endocrinology. This article summarizes its findings.

In order to see how acupuncture might have an effect on chronic stress, the researchers chose common hormones and neurotransmitters present under stress. These could serve as markers for stress because there is more of each when there is a natural response. The subjects were not human, but animal- lab rats- because they also release these substances as a natural response, in this case, temperature change, to which the HPA and SNS are very sensitive. The acupuncture points were needled with the addition of an electrical lead (electro-acupuncture), for greater measuring accuracy.

The researchers measured the effects of acupuncture on stress response by blood test, over a 10-day period. There were four distinct groups to measure and compare against each other.

1. Group 1: No stress and no acupuncture- this is the control group.
2. Group 2: Subjected to cold temperature for one hour a day with no acupuncture.
3. Group 3: Subjected to cold temperature for one hour a day and treatment of “sham” acupuncture- needled in a random, non-acupuncture point (near the tail).
4. Group 4: Subjected to cold temperature for one hour a day and treatment of electro-acupuncture at a significant acupuncture point ST 36.

Group 1 was the control group: they had no stress and no acupuncture. Both Groups 2 and 3 had elevated levels of the hormones and neurotransmitter. Group 4 had reduced levels of all three, almost as low as the control group, and significant for reduction of HPA activity.

The researchers’ conclusion was that the pathways for these biochemical were blocked by the electro-acupuncture in Group 4, resulting in lessened stress response.

Afterthought: any method, modality, or medical intervention that reduces stress by regulating body systems is of benefit to human health. Examples of each might be meditation, acupuncture, or prescription drugs. It bears repeating that the conclusion in this study has broad implications for the future of acupuncture within the cross-section of chronic pain, stress, and achieving a steady state of wellbeing. More research needs to be done on the intersection of acupuncture and additional body systems such as the Inflammatory and Immune Response as well as other structures in the brain.

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At Mountaintop Acupuncture, we have a combined 34 years of experience. To read more, please click here.

If you have questions and concerns about acupuncture treatment, we offer a free 20-minute phone session: click here for contact information to call or e-mail us. We practice at The Highlands Ranch Medical Pavilion in Littleton, Colorado.

Insurance is welcome and accepted.

Stress, Your Brain, and Feeling Whole, Part I

Brain illustration courtesy of The Human Brain Book
by Rita Carter

A recent study of interest looks at the intersection of the nervous system and acupuncture, and some brain anatomy and physiology might be helpful, so here it is, in a nutshell:

The hypothalamus-pituitary-axis (HPA) is a region in the brain that has to do with regulation of a multitude of body functions, from immunity, to reproduction, digestion, and temperature.

The sympathetic nervous system (SNS) is our “fight or flight” system that helps us survive.

The hypothalamus acts as the intermediary between the nervous system and the endocrine system, and the pituitary is the body’s major endocrine gland.

The hypothalamus-pituitary-axis and sympathetic nervous system work ceaselessly to attain and maintain homeostasis, the natural state of equilibrium, in the entire body.

The two hormones from the HPA were ACTH (adrenocorticotropic) and CORT (corticosterone); the peptide from the sympathetic nervous system (SNS) was NPY (neuropeptide Y).
ACTH, CORT, and NPY are present in abundance when the both systems are activated.

The hormones and neurotransmitter measured were obtained by blood tests over 10 days.

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At Mountaintop Acupuncture, we have a combined 34 years of experience. To read more, please click here.

If you have questions and concerns about acupuncture treatment, we offer a free 20-minute phone session: click here for contact information to call or e-mail us. We practice at The Highlands Ranch Medical Pavilion in Littleton, Colorado.

Insurance is welcome and accepted.

Finding Quality Research for Medical Conditions, in a Nutshell

path_1Have you had this experience? You go to the doctor, get a diagnosis, and then try to figure out what your doctor said, and what you’re going to do to get better.

This post is a nutshell guide to orienting yourself when the need arises. At Mountaintop Acupuncture, we’re big believers in being proactive. We find when we do a little responsible research, we’re able to make clearer decisions about our health.

Getting information on a condition helps us understand how the problem may have arisen, understand what the tests and treatment options are, and communicate to find the best ways to get better.

We recommend the following sites, because they provide information that is based on quality scientific research.

  • Basic Level

Medline Plus: overview of common symptoms, treatment options, management strategies of many medical conditions.

Mayo Clinic: a little more detail, stated differently, which allows you to compare and contrast the basic information, helping you orient yourself and deepen your understanding.

  • Intermediate Level

Cochrane Reviews: meta-analyses of published studies.

British Medical Journal: published studies.

  • Complex Level

PubMed: abstracts of published studies.

Minimizing Bias

Research studies of the highest quality are based on standards that seek to minimize bias when collecting data and analyzing it. Quality studies are the polar opposite of “he said, she said.”

Studies must meet the following criteria in order for money and time to be invested:

  • Outline the objective, method, and design of the study, with a complete review of related literature published to date.
  • Be affiliated with institutions that provide the ethical and scientific checks and balances, to ensure minimum bias and error.

There are many types of studies:

  • Randomly Controlled Trial is the research study gold standard in medicine. The RCT gathers information through a rigorous process that mathematically must have minimum bias and error built into its design. The RCT uses human subjects to find out the usefulness of healthcare practices. Built into it is the idea of chance: do some people get better because of other factors, or is the drug/device/protocol/healthcare practice of significant benefit?
  • The Large Prospective Study is also highly regarded, because it measures outcomes in the same participants, over a long period of time. Large Prospective Studies provide an opportunity to collect and analyze related data, often resulting in unexpected, useful findings. An example of this is the Women’s Health Initiative, which collected data for 12 years, from 1992-2004, from a large sampling of women. One arm of the study followed breast cancer incidence and hormone replacement therapy, ultimately leading the scientific community to agree to change methodologies in treatment of menopausal women.
  • The Systematic Reviews and Meta-Analyses look at all the studies that have been done on a given subject, to verify the findings of current research, including acknowledgement of weaknesses or shortfalls in the conclusions.

Not all studies are equal, so when you find a favorable study on your subject of interest, it is important to assess several factors: the who, what, where, and why of it. For example, how many participants are in the study, what methodology and design was used, the authors, the institution involved, the publishing journal. In future posts, we will cite some studies and point out some of these legitimizing details.

http://mountaintopacupuncture.com/researching-medical-conditions-on-the-internet

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At Mountaintop Acupuncture, we have a combined 34 years of experience. To read more, please click here.

If you have questions and concerns about acupuncture treatment, we offer a free 20-minute phone session: click here for contact information to call or e-mail us. We practice at The Highlands Ranch Medical Pavilion in Littleton, Colorado.

Insurance is welcome and accepted.

The Limbic System and Acupuncture

fMRI of Limbic System sections, courtesy of the NIH

Previously we published an article on the Limbic System, describing its function and positing acupuncture’s effects on it. This month, we found a study that supports this idea: Effects of Electroacupuncture versus Manual Acupuncture on the Human Brain as Measured by fMRI, published in the academic journal Human Brain Mapping in 2005.

This study was funded by the NIH and conducted by Harvard University at Massachusetts General Hospital. Researchers used fMRI’s on 13 healthy participants. Brain activity was measured at just one acupuncture point, ST 36, using four mechanisms:
1. manual acupuncture
2. electrical stimulation at 2 Hz
3. electrical stimulation at 100 Hz
4. placebo acupuncture creating a tactile sensation as a control

Please note: electrical stimulation utilizes a machine that attaches to the needles to amplify their effect. ST 36 is a major, commonly-used point for its many functions supporting overall health. For those of you who receive acupuncture treatment, it is located below the knee, on the outer side of the leg.

While the researchers found that electrical stimulation increased desirable effects in specific regions of the brain, overall their study supported the “…hypothesis that the limbic system is central to acupuncture effect regardless of specific acupuncture modality.”

To read this study is humbling, for it requires advanced knowledge of the brain’s anatomy and physiology. In a nutshell, it found the first three mechanisms listed above had a regulating effect on the limbic system, while the placebo of tactile control had little or no change. That is, where it is beneficial for activity to increase (a biological call to action) or to decrease (a biological call to calm), real acupuncture, with the help of the electrical stimulation machine or alone, affected this part of the nervous system in the manner intended.

http://mountaintopacupuncture.com/the-limbic-system-and-acupuncture

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At Mountaintop Acupuncture, we have over 30 years experience. To read more, please click here.

If you have questions and concerns about acupuncture treatment, we offer a free 20-minute phone session: click here for contact information to call or e-mail us. We practice at The Highlands Ranch Medical Pavilion in Littleton, Colorado.

Insurance is welcome and accepted.

Endocrine System Overview

The seat of the pituitary gland

The seat of the pituitary gland

The body’s metabolic functions are set in motion by a series of electrical and chemical reactions that keep its systems running smoothly. In order for us to have a good quality of life, each body system must work efficiently and harmoniously with the other systems. Therefore, it is critical that there be a communication network for this to occur. We have already touched upon one of the communication systems, the nervous system, now here is an overview of the endocrine system.

The endocrine system (ES) and the nervous system (NS) are intrinsically connected, regulating all the body’s activities. The NS uses electrical conduction along nerves to communicate, whereas the ES uses chemical messengers, via the bloodstream, to signal for a physical reaction to occur.

The ES uses two types of glands to deliver its chemical messages as hormones: the endocrine and exocrine glands.

  1. Exocrine glands secrete hormones or other substances into body cavities and onto the body surface using ducts
  2. Endocrine glands are ductless and secrete hormones directly into the bloodstream

Hormones are made up of amino acids or lipids and act as messengers that reach its target cell. Practically every cell has the ability to secrete and receive a hormone or hormone-like chemical, to elicit the desired changes needed to create balance.

The communication between the nervous system and the endocrine system happens between the hypothalamus, located in the brain, and the pituitary gland. This relationship is called the hypothalamus-pituitary-adrenal axis, and is key to how we deal with any kind of stress. The autonomic nervous system recognizes a stressor and commands the release of hormones from the hypothalamus to the pituitary gland, in order to stimulate or inhibit the secretion of regulatory hormones. This series of events creates a cascade of reactions in the body, depending upon the stressor.

The hypothalamus is a powerhouse, with many diverse functions. In addition to working with the pituitary gland to release and stimulate many hormones, the hypothalamus is a relay center for autonomic functions associated with digestion and plays a role in the alerting system, body temperature control, our sleep, our sense of pleasure and other emotional behavior, and hunger and satiety.

The pituitary gland is known as the “master gland” because of its regulatory affect on the other endocrine glands that control many metabolic activities. The pituitary gland lies below hypothalamus and sits in the center of the sphenoid bone on the sella turcica (Turkish Saddle). The sphenoid bone is the floor of the cranium, and connects with all the bones of the skull, with the exception of the mandible.

Another close connection between the NS and the ES are the messenger substances, the neurotransmitters and hormones. These two chemicals are the same, except that neurotransmitters are chemicals released at the end of the nerve’s axon, and hormones, as previously mentioned, are released from glands.

Hormones can either stimulate or inhibit a reaction. The endocrine system’s hormones can have a long-lasting effect on the body, from hours to weeks. Excessive and sustained stress and anxiety can affect the NS, keeping the body’s natural balance from correcting itself, potentially creating future problems. Some of the diseases of the ES are the result of hyper-secretion (hormone excess), hypo-secretion (hormone deficiency), or tumors (malignant or benign).

Acupuncture and Chinese herbs have been shown to have a regulating effect on the nervous system, and so by extension, the endocrine system. It is recommended to get a yearly physical that includes blood tests of hormone levels. Early detection can manage and in some cases eradicate a problem, using western medicine protocols in conjunction with acupuncture and Chinese herbs.

http://mountaintopacupuncture.com/endocrine-system-overview

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At Mountaintop Acupuncture, we have over 30 years experience. To read more, please click here.

If you have questions and concerns about acupuncture treatment, we offer a free 20-minute phone session: click here for contact information to call or e-mail us. We practice at The Highlands Ranch Medical Pavilion in Littleton, Colorado.

Insurance is welcome and accepted.